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KMID : 0358819900170030322
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1990 Volume.17 No. 3 p.322 ~ p.328
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AN EXPERIMENTAL STUDY ON THE BONE REGENERATION WITHIN A PYROST®(POROUSHYDROXYAPATITE) IN THE RAT
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Choi Jeong-Ho
Choi Eung-Ok
Chung Chun-Eun
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Abstract
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PPYROST® is a biocompatible porous matrix implantable as a bone graft substitute. This biomaterial has been used in a variety of experimental settings over the past years and more recently has been used in clinical applications for the filling of bone defects.
its use in human may help to eliminate the morbidity of autogenous bone graft donor sites and r,-sorption of autogenous bone graft.
We studied the new bone regeneration within a PYROST19 block, which were placed end to end in a subperiosteal pocket on the nasal dorsum of 1.8-2.0 Kg New Zealand white rabbit. En block specimens were harvested at 4.8 and 12 weeks post onlay. These were then decalcified. imbedded and sectioned in the sagittal plane. For the confirmation of bone regeneration within a PYROSTO we used weighing the PYROST® and light microscope, point-counting technique and fluorescent microscope. The results obtained were summarized as follow
1. There was no volume change of PYROST®
2. The activation of osteoblasts and bone matrix were found of 4 weeks and matrix of lainellar pattern was found 12 weeks post onlay.
3. The quantity of the regenerated new bone within a PYROST® was increased at 12 weeks (32±2.1 %) than 4 weeks (15±1.8%).
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KEYWORD
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